Diethylnitrosamine Initiation Does Not Alter Clofibric Acid–Induced Hepatocarcinogenesis in the Rat
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چکیده
منابع مشابه
Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse
Nuclear receptor coactivator [peroxisome proliferator-activated receptor-binding protein (PBP)/mediator subunit 1 (MED1)] is a critical component of the mediator transcription complex. Disruption of this gene in the mouse results in embryonic lethality. Using the PBP/MED1 liver conditional null (PBP/MED1(DeltaLiv)) mice, we reported that PBP/MED1 is essential for liver regeneration and the pero...
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Kinetics of hepatocarcinogenesis was evaluated in 15-day-old male C57BL/6J X C3HeB/FeJ F1 mice using a nontoxic carcinogenic dose range of diethylnitrosamine (DEN). The carcinogen was injected i.p. once, and the animals were killed according to the protocol. Two studies were carried out sequentially over a period of 4 years. In the first study, groups of mice were treated with 0.625, 1.25, 2.5,...
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J. Deng, N. Jin, G-Y. Yang, R. A. Omary, and A. C. Larson Department of Radiology, Northwestern University, Chicago, IL, United States, Department of Medical Imaging, Children's Memorial Hospital, Chicago, IL, United States, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-0929,1096-6080
DOI: 10.1093/toxsci/kfm168